Metoclopramide or reglan metoclopramide is a bowel stimulant, and works best to help the stomach to empty.
Absorption of drugs from the stomach may be diminishede.gdigoxinby metoclopramidewhereas the rate and/or extent of absorption of drugs from the small bowel may be increasede.gacetaminophentetracyclinelevodopaethanolcyclosporine
Reglan Injectionmetoclopramide hydrochlorideUSPis indicated for the relief of symptoms associated with acute and recurrent diabetic gastric stasis.
Rarelycases of hepatotoxicitycharacterized by such findings as jaundice and altered liver function testswhen metoclopramide was administered with other drugs with known hepatotoxic potential.
Care should be exercised in administering metoclopramide to neonates since prolonged clearance may produce excessive serum concentrationssee CLINICAL PHARMACOLOGYPharmacokineticsIn additionneonates have reduced levels of NADH-cytochrome b 5 reductase whichin combination with the aforementioned pharmacokinetic factorsmake neonates more susceptible to methemoglobinemiasee OVERDOSAGE
Metoclopramide therapy should be discontinued in patients who develop signs or symptoms of tardive dyskinesiaThere is no known treatment for tardive dyskinesiaIn some patientssymptoms may lessen or resolve after metoclopramide treatment is stopped.
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